For applications where pure CBD isn’t required, full spectrum CBD oil is the better alternative, as it provides patients the ancillary benefits associated with the many other cannabis compounds. However, important to note, is the issue of what medical conditions are best treated by either pure or full spectrum CBD oil, given the research is in its infancy.
Cutting-edge science has shown that the endocannabinoid system is dysregulated in nearly all pathological conditions. Thus, it stands to reason that “modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans,” as Pal Pacher and George Kunos, scientists with the U.S. National Institutes of Health (NIH), suggested in a 2014 publication.
CBD oil took the world by storm a few years ago when Dr. Sanjay Gupta investigated the cannabinoid’s ability to treat children with epilepsy. Initially, CBD oil was viewed as a medicine for the critically ill, but its appeal to the general public is surging. With few regulations, the CBD oil market is congested with questionable products. As a consumer of CBD oils, it is essential for you to know how they are made.
Dr. Devinsky’s research, which was recently published in The New England Journal of Medicine, is beginning to provide that much-needed data in the field of epilepsy research. In a landmark multinational randomized double-blind study for a treatment-resistant form of the condition, subjects taking an oral solution of 20 mg CBD per kilogram of body weight for 14 weeks, along with standard treatment, experienced a 42 percent reduction in drop seizures (the muscles go limp). Those taking a 10 mg CBD per kilogram of body weight saw a 37 percent decrease; patients who got a placebo saw a 17.2 percent decrease. The mechanism hasn’t quite been worked out yet, Dr. Devinsky says, though there’s some evidence that a receptor known as GPR55 may be critical for the anti-seizure effect.
Full-spectrum hemp oil refers to when the pure oil extracted from hemp contains all the same cannabinoids and compounds found in the original hemp plant. Unlike isolated or synthetic cannabinoids, full-spectrum hemp oil contains an array of cannabinoids, as well as many essential vitamins and minerals, fatty acids, protein, chlorophyll, fiber, flavonoids, and terpenes.
When extracting a pure botanical oil from hemp, a solvent is passed through the plant material, pulling the compound rich oil from the plant. The solvent is then removed in a purging process, leaving behind a concentrated oil. When extracting from hemp, the oil can next be formulated into finished products or further refined and purified into a number of forms, including a golden dewaxed concentrate or crystallized CBD isolate.
Supercritical CO2 extraction is also the key to understanding more cannabinoids in cannabis like Cannabichromene (CBC) and cannabicitran (CBT) and how they interact with each other (called the Entourage effect). This can lead to increased understanding of marijuana in the medical field, and will also allow growers to come up with more effective, new and exciting strains.
Herrera and her patients aren't the only ones doling out rave reviews for CBD oil, which can be found online and in cannabis dispensaries, as well as in some grocery stores and even as an optional add-in alongside protein powder at your local juice chain. The oil has been riding the coattails of the growing legal cannabis industry, with one industry expert, Matt Karnes, telling Forbes in 2016 that he expected CBD products to become an almost $3 billion market by 2021.
Isolates are typically the CBD oil product of choice for those who get drug tested or are sensitive to other cannabinoids such as THC. Products labeled as isolates will generally be highlighted as being 99+% “pure CBD.” Usually, these products will have nothing but CBD in them because the CBD has literally been isolated from everything else. You can find pre-made isolate oils that typically consist of a carrier oil, such as MCT oil, infused with the crystalline isolate powder. You can also find the “raw” CBD crystalline powder or slabs (a form of concentrate) on its own.
To extract, you soak the hemp plant in a solvent, such as grain alcohol. After the material soaks, the remaining liquid contains CBD and the other cannabinoids from the pant. Once you evaporate the solvent, the CBD hemp oil remains. The oil is then ready to either consume or add to edible products. Commercial producers have adopted and modified Mr. Simpson’s method. CBD hemp oil producers use ethanol to extract CBD.
And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
CBD isolate is pure CBD, extracted and purified until none of the plant’s other constituent compounds remain. It has been isolated down to just the CBD molecule. This purity and potency is why it’s the preferred treatment for patients needing unadulterated doses of CBD and nothing else. It has no other active ingredients and its purpose is simply to deliver therapeutic doses of CBD. CBD isolate products often come as a white powder or a mix with a oil.
There's also the question of CBD's legality – something that's a lot grayer than the black-and-white picture most companies paint. The U.S. Drug Enforcement Administration considers CBD, like all cannabinoids, a schedule 1 drug. That means it's just as illegal as heroin and ecstasy. Meanwhile, hemp – a variety of the cannabis plant regulated by the U.S. Department of Agriculture – is legal , so long as its THC content is negligibly low. But because the agriculture department doesn't test for CBD – only THC – in hemp, more companies are getting away with selling products they say contain CBD, says Sara Jane Ward, an assistant professor of pharmacology at the Temple University Lewis Katz School of Medicine who's been studying CBD in rodent models for more than 10 years. Needless to say, the legality of CBD is "very confusing and very gray," she says.
The key difference between hemp and marijuana is that hemp contains practically zero THC. In fact, in order to be classified as hemp, a cannabis plant must contain less than 0.3% THC by volume. This is really important because it’s actually the reason why hemp products are legal to buy, sell, and ship. If they don’t get you high, then why would they be illegal?
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
Full spectrum (or “whole plant”) products contain CBD as well as terpenes and other cannabinoids such as CBG, CBN and trace amounts of THC. Usually these will be in ratios that were naturally-occurring and extracted from the plant and specific strain. Terpenes and cannabinoids are occasionally added back into products as an isolated form to raise the potency of the product.
There is a strong sedative quality to CBD hemp oil, making it a popular remedy for people with insomnia, sleeplessness, interrupted sleep, post-traumatic stress disorder, restless leg disorder, and other night-time issues. Dr. Scott Shannon, Assistant Clinical Professor of Psychiatry at the University of Colorado School of Medicine, USA, published a report in the Permanete Journal, in which he recommended either inhaling a small amount of CBD oil, applying it to one’s chest, or even putting a few drops on one’s pillow to help get a good night’s sleep.
It probably depends on each individual’s preference, but many researchers support the effects of the full spectrum CBD. They say that the full spectrum’s healing factors through the “entourage effect” are very useful for the treatment of any of the chronic condition. This is why the full spectrum CBD has to be part of the ingredients, not the isolate non-pure one.
The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide far better performance than any single compound alone, and that includes CBD. Here are a couple of examples of conditions that benefit from the entourage effect:
Officially, marijuana is deemed as Schedule I herbal substance by the U.S. Drug Enforcement Administration, meaning the drug offers "no currently accepted medical use and a high potential for abuse," according to the federal government. That categorization was adjusted after the passage of the 2018 Farm Bill, which included a provision that separated hemp from marijuana, as noted in the Controlled Subject Act.
Some work-place drug screens and tests detect THC and not the presence of Cannabinoids or other legal hemp based constituents. However, studies have shown that ingesting hemp can cause confirmed positive results. Based on this information, if you are subject to any form of drug screening or testing or are a member of the United States Armed Services, we cannot recommend that you ingest this product. Please consult with your healthcare practitioner as well as your employer or drug screening company.
First, ethanol is a polar solvent. This means that it will readily mix with water and dissolve water-soluble molecules. This creates a great challenge for companies using the ethanol extraction method because chlorophyll is one of the compounds that will easily co-extract. Chlorophyll in the concentrate will result in a dark green coloring and an unpleasant bitter, grassy flavor.
Dosage is important, because CBD can have side effects—the most common are tiredness, diarrhea, and changes in appetite and weight—so it’s best not to take more than you need. As CBD becomes more prevalent, says J. Michael Bostwick, M.D., a psychiatrist at Mayo Clinic in Rochester, MN, “I’m reasonably certain new kinds of side effects will emerge.”
Each bottle of Bluebird Botanicals CBD oil comes with a precise dropper, making it easy to measure your exact serving size and adjust it according to your body’s needs. This also allows you to easily combine the CBD oil with any other CBD product to introduce more variety and enrich your daily CBD experience. You can try the Classic Hemp oil alongside any CBD edible or right before your CBD vape for a synergistic effect.
Answering the question “what is CBD oil” would be incomplete without mentioning the many CBD oil benefits. In addition to positively affecting the endocannabinoid system, CBD has been the focus of more than 23,000 published studies about cannabinoids in relation to various medical indications including anxiety, epilepsy, inflammation, cancer and chronic pain to name few. You can even find CBD for pets that is specially formulated to safely allow your pets to experience the natural benefits of CBD. For a more comprehensive look at these and other studies, visit our medical research and education page. Stay up-to-date on the latest developments in CBD and cannabis in our medical marijuana news section.