Given CBD’s reputation as a popular, artisanal remedy, one would think that Epidiolex would command a lot of “off label” attention. After all, physicians often prescribe pharmaceuticals off label to treat conditions that were not the actual focus of clinical trials. But the costly price tag for Epidiolex (more than $30,000 annually) precludes off label prescribing as well as affordable access for tens of millions of Americans without health insurance.
CBD and THC interact with our bodies in a variety of ways. One of the main ways they impact us is by mimicking and augmenting the effects of the compounds in our bodies called “endogenous cannabinoids” - so named because of their similarity to the compounds found in the cannabis plant. These “endocannabinoids” are part of a regulatory system called the “endocannabinoid system”.
First you need to realize that there are more than 70 different cannabinoids that have been identified so far and over 500 constituents of cannabis including various terpenoids and flavonoids. In fact, the US government holds multiple patents on various cannabinoids. They also hold patents defining these cannabinoids many medical benefits. One of these cannabinoids which has shown a huge amount of potential is CBD or Cannabidiol and while its potential could not possibly be understated there is another cannabinoid making headlines as well. Tetrahydrocannabidiol otherwise known as THC.
‘The media has no doubt helped drive this popularity,’ says Dr Sarah Brewer, medical director at Healthspan. ‘However, the main drive is because people who take it experience the benefits very quickly, and “word of mouth” is a powerful thing. CBD oil also has such a wide range of benefits, reducing anxiety, promoting relaxation, ensuring a good night’s sleep, reducing pain perception and improving general feelings of wellbeing. It therefore appeals to a wide range of people.’
Since it is non-toxic and non-flammable, supercritical CO2 is preferable over chemical solvents like butane, hexane, and acetone, which can linger in the extracted oil if not purged correctly, rendering the oil toxic. It has also been noted that botanical essential oils extracted using supercritical CO2 are truer to the scent of the original plants than in other forms of extraction, meaning more of the plant’s chemical structure is retained in the oil with the use of CO2.
There is a strong sedative quality to CBD hemp oil, making it a popular remedy for people with insomnia, sleeplessness, interrupted sleep, post-traumatic stress disorder, restless leg disorder, and other night-time issues. Dr. Scott Shannon, Assistant Clinical Professor of Psychiatry at the University of Colorado School of Medicine, USA, published a report in the Permanete Journal, in which he recommended either inhaling a small amount of CBD oil, applying it to one’s chest, or even putting a few drops on one’s pillow to help get a good night’s sleep.
In the United States marijuana is still listed under Schedule I of the Controlled Substances Act. However, the federal Food and Drug Administration (FDA) has authorized clinical trials on a CBD-based drug that treats childhood-onset epilepsy. CBD oil also shows promise in treating intestinal conditions as well as anxiety, post-workout aches, inflammation, and some types of cancers. Additional conditions are neurological inflammation, oxidative injury, and schizophrenia.
Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.
At least one benefit of CBD is well-supported by science: It can be effective in treating children with rare, genetic seizure disorders. Adults, children and even animals with epilepsy have been shown to benefit from the chemical too, the World Health Organization reports. There's also some evidence that CBD can help with anxiety, says Dr. Robert Carson, an assistant professor of neurology and pediatrics at Vanderbilt University who focuses on children with epilepsy. "In children, especially those with autism spectrum disorders, this may manifest as improved interactions with others," he says. Other preliminary research shows CBD holds promise for conditions including Alzheimer's disease, cancer, psychosis and Parkinson's disease – and is pretty much impossible to abuse or become addicted to, WHO says.
Anyway, the research showed that in mice, CBD was much more effective when used along with other compounds of the cannabis plant, than when it was used by itself. While they haven’t yet figured out why exactly this is the case, it’s now generally accepted that full-spectrum CBD oil is more effective at treating the majority of medical conditions, than is CBD isolate.
Now that cultivation of hemp has become legal in some parts of the world there are widespread discussions about how the medicinal properties of CBD oil is curing people of varied illnesses. Since it is derived from hemp which is a strain of cannabis, people had apprehensions about this product but now with widespread media coverage usage has become common in therapy clinics. CBD is one of the many cannabidiols that exist naturally in the Cannabis plant along with THC.There is difference between plants rich in CBD and those rich in THC as the former is called indica-dominant plants while latter is sativas rich plant. While sativas rich plants give an uplifting feeling, the indica rich plants give the body a relaxed feeling that is ideal for people in acute pain.
The appeal? Proponents claim CBD can help ease pain, anxiety, depression and stress, boost focus and productivity, improve the immune system, reduce inflammation and more. And – unlike its psychoactive cousin THC – CBD, they say, is harmless, legal and can't get you high. "The known is it's good for you, it helps a lot of people and a lot of things, and you can't hurt yourself," says Phil Asquith, a farmer and producer of extra-virgin olive oil in California, who founded one of the first companies in the CBD space. "The unknown is all the details."
“There’s no oversight,” says Marcel Bonn-Miller, PhD, adjunct assistant professor of Psychology in Psychiatry at the University of Pennsylvania and author of the JAMA article. Beyond the label, he adds, “There’s no consistency. You know that every Hershey’s bar you buy and every Coke you buy will be exactly the same. But that’s not the case with the majority of CBD products. It’s not unexpected to see variability within a given brand.” This means that you may notice improvements the first time you buy and try a particular product, but none the next.
If this is not sufficient for calming your symptoms, a gradual increase of another 25 mg per day, over the course of 3-4 weeks, is recommended. While there have been no reports of more serious side effects when this oil is taken in larger concentrations, it is best to slowly increase your dose to find a comfortable and effective level, given your individual characteristics and needs.
What a great article. I have learned a lot on CBD/Hemp. I personally have testimonials that prove that it works and changes lives. My father for one has anxiety and it has helped him tremendously. There are so many benefits but not enough time to mention. I do know it works but I also know not all are equal. There are 5 things you really need to look for when picking one.
Each bottle of Bluebird Botanicals CBD oil comes with a precise dropper, making it easy to measure your exact serving size and adjust it according to your body’s needs. This also allows you to easily combine the CBD oil with any other CBD product to introduce more variety and enrich your daily CBD experience. You can try the Classic Hemp oil alongside any CBD edible or right before your CBD vape for a synergistic effect.
CBD—or cannabidiol—is a type of cannabinoid, a family of molecules typically associated with marijuana, but in fact, also found in other plants and even humans (in us, they’re called endocannabinoids). There are hundreds of different cannabinoids in marijuana. The best known is tetrahydrocannabinol, or THC, a chemical in marijuana that targets and binds to certain receptors in the brain to give you a high. CBD is non-psychoactive and non-addictive, and it seems to bind to multiple target sites, thereby affecting a range of systems throughout the body.
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
In another, a specific combination of CBD and other secondary cannabinoids were found to work together to slow tumor grown in cases of colon cancer. These sorts of synergistic effects are fairly common in whole plant extracts, and aren’t unique to cannabis. However, the sheer volume of active compounds in cannabis extracts, and their wide-ranging effects certainly distinguish them from other plants.
There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
While it is clear that full spectrum CBD may be more effective than isolate CBD, even at lower dosages, it may have some drawbacks. Full spectrum vs regular CBD comes down to this drawback for many people. If full spectrum CBD oil is not an option for you due to your obligations or lifestyle, this can help you make your decision more easily for sure.