Unlike THC, which primarily binds to CB-1 receptors located in the brain, CBD works in the body by manipulating receptors throughout organ tissues, the immune system, the pain response system, the hormonal system, and other whole-body regulatory systems. Basically, since its receptors have been found to exist in virtually every cell and tissue type in the body, CBD is believed to work on every aspect of human health and behavior – from the subcellular level to the whole-body leve and beyond.

Hemp is possibly one of the earliest plants to be cultivated.[106][107] An archeological site in the Oki Islands near Japan contained cannabis achenes from about 8000 BC, probably signifying use of the plant.[108] Hemp use archaeologically dates back to the Neolithic Age in China, with hemp fiber imprints found on Yangshao culture pottery dating from the 5th millennium BC.[105][109] The Chinese later used hemp to make clothes, shoes, ropes, and an early form of paper.[105] The classical Greek historian Herodotus (ca. 480 BC) reported that the inhabitants of Scythia would often inhale the vapors of hemp-seed smoke, both as ritual and for their own pleasurable recreation.[110]
CBD is the major non-euphorigenic component of Cannabis sativa. Some research is beginning to show that CBD is different than other well-studied cannabinoids. All cannabinoids function as ligands, meaning they dock onto the binding site of a protein and have the ability to modulate a receptor’s behavior. CB1 receptors are widely distributed, but are particularly abundant in areas of the brain, including those concerned with movement, coordination, sensory perception, emotion, memory, cognition, autonomic and endocrine functions.
CBD has been shown to interact with the body’s endocannabinoid system, a network in the brain that seems to play a role in social behavior, circadian rhythm, and reward processing—all of which can be atypical in people with autism. For that reason, researchers are excited about a study that’s currently underway at the University of California San Diego about CBD’s potential as an autism therapy.
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So, if it’s not psychoactive, what exactly is hemp used for? Ever since the Neolithic Age when farmers in China first cultivated this plant, the use of hemp grew in order to fulfill many different needs people had through history. It is now used to make clothing, biofuels, foods, health products, body care products and even plastic composites. One source suggests that this “magical plant” is currently used to create more than 25 thousand different products – as many as petroleum. The U.S. hemp industry was estimated to be worth around 500 million USD in annual retail sales in 2012, and this number is quickly trending upward, according to Hemp Industries Association.
CBD oil is prohibited for sale by terms of service on the major online marketplaces, including Amazon, eBay and Groupon. Most of the products being sold as CBD oil on those websites are hemp seed oil and don’t contain any CBD. We’ve also heard many reports of counterfeit and potentially dangerous products being sold as CBD oil on those websites. Your best bet is to always buy directly from the CBD company’s official website.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
In this review, the effects of cannabinoids in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-adrenal cortex axis. Cannabis users have reduced levels of gonadotropins, reduced prolactin and growth hormone. Cannabis affects corticotropin-releasing hormone-, thyrotropin-releasing hormone-, vasopressin-, and oxytocin-expressing neurons. Therefore, our findings reveal a mechanism of rapid glucocorticoid feedback inhibition of hypothalamic hormone secretion via endocannabinoid release in the paraventricular nucleus of the hypothalamus and provide a link between the actions of glucocorticoids and cannabinoids in the hypothalamus that regulate stress and energy homeostasis. Glucocorticoid negative feedback in the brain controls stress, feeding, and neural-immune interactions by regulating the hypothalamic-pituitary-adrenal axis. Cannabis increases dopamine which decreases prolactin. Cannabis decreases oxytocin, thyroid hormone and growth hormone, and disrupts the hypothalamic-pituitary-adrenal axis. Cannabinoids suppress fertility via reducing hypothalamic gonadotropin- releasing hormone output. γ-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to gonadotropin releasing hormone cells that can be excitatory. Cannabinoids act via inhibiting GABAergic input. Cannabis disregulates the hypothalamic-pituitary-adrenal axis circadian rhythm. Cannabis decreases serum concentrations of pituitary gonadotropins. Cannabis raises cortisol and ACTH which increases cortisol which uses up progesterone reducing testosterone and estrogen. Cannabis lowers testosterone in men by inhibiting testosterone secretion and impairs fertility in males through alteration in the testicular endocannabinoid system. Cannabis suppresses copulatory behavior even when testosterone levels are maintained. It decreases sperm concentration, causes defective sperm function or alteration of sperm morphology. Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. Testicular degeneration and necrosis is induced by chronic administration of cannabis. In both ovulating and menopausal women, cannabis can alter pituitary gonadotropin release and alter metabolism or target tissue response to gonadal steroids, leading to reduced estrogen and progesterone production and anovulatory menstrual cycles. Cannabis presents abnormal longer ovulatory cycle lengths in females. Cannabis suppresses luteinizing hormone when sex hormones are initially high, but, chronic cannabis lowers progesterone and testosterone in men, and lowers estrogen and progesterone in women, so luteinizing hormone significantly increases which raises night time core temperature for disrupted sleep. Cannabis increases hypothalamic nitric oxide which inhibits oxytocin. Cannabis is detrimental for lactating moms. Cannabis decreases maternal care, decreases aggressive instinctual behaviors for protection of young, suppresses maternal anxiolysis, decreases plasma oxytocin levels and milk consumption and decreases activation of oxytocinergic neurons in hypothalamic nuclei. Changes in the behavioral responses of lactating mothers treated with cannabis can be related to disruption in the neuroendocrine control of oxytocin secretion. Cannabis causes impairment of glucocorticoid feedback which either enhances or decreases performance on various tasks. Cannibis can cause a decrease in thyroid which negatively affects cerebellar development and motor performance involved in adult brain function. It induces consistent behavioral changes in adults, leading to severe anxiety and morphological changes in the hippocampus, however, it shows improvements for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side. Cannabis and Δ(9) -THC are anticonvulsant in most animal models but can be proconvulsant in some healthy animals. The simultaneous rapid stimulation of nitric oxide and endocannabinoid synthesis by glucocorticoids has important implications for the impact of stress on the brain as well as on neural-immune interactions in the hypothalamus. Cannabis has implications for psychosis. There are blunted psychotomimetic and amnestic effects with cannabis. Lithium increases oxytocin and helps in cannabis withdrawal, and pregnenolone/progesterone help in cannabis withdrawal as estrogen generally increases and progesterone decreases sensitivity to marijuana.
If the information on the official website is anything to go by, Green Roads indeed screens a multitude of compounds during their testing. Apart from testing for heavy metals, residual solvents, microbial contaminants, and other toxins, the company also looks for cannabinoids and terpenes individually. While there is no denying that Green Roads has firmly cemented its position as a leader in the CBD oil circles, the source of its hemp isn’t apparent.
Hemp is possibly one of the earliest plants to be cultivated.[106][107] An archeological site in the Oki Islands near Japan contained cannabis achenes from about 8000 BC, probably signifying use of the plant.[108] Hemp use archaeologically dates back to the Neolithic Age in China, with hemp fiber imprints found on Yangshao culture pottery dating from the 5th millennium BC.[105][109] The Chinese later used hemp to make clothes, shoes, ropes, and an early form of paper.[105] The classical Greek historian Herodotus (ca. 480 BC) reported that the inhabitants of Scythia would often inhale the vapors of hemp-seed smoke, both as ritual and for their own pleasurable recreation.[110]
However, if it was sourced from actual marijuana (i.e. cannabis that contains more than 2% THC by volume), then it is technically illegal. Most of the best CBD oils for pain that you find in dispensaries in states like Colorado, California, and Washington (as well as other states where weed is legal) will have been extracted from marijuana plants — not industrial hemp plants. Unfortunately, this means that these products are not allowed to be sold online and shipped across state lines to “non-legal” states.
Since the passing of the 2014 Farm Bill, however, there are a handful of states that have begun growing hemp in the US. This has led to a noteworthy increase in domestic production, as well as increased options for quality industrial hemp-derived CBD products. Domestic industrial hemp must be certified and registered in the state its grown in, which upholds growers to much stricter standards than are found overseas.
Hemp fiber has been used extensively throughout history, with production climaxing soon after being introduced to the New World. For centuries, items ranging from rope, to fabrics, to industrial materials were made from hemp fiber. Hemp was also commonly used to make sail canvas. The word "canvas" is derived from the word cannabis.[25][26] Pure hemp has a texture similar to linen.[27] Because of its versatility for use in a variety of products, today hemp is used in a number of consumer goods, including clothing, shoes, accessories, dog collars, and home wares. For clothing, in some instances, hemp is mixed with lyocell.[28]

   Industrial hemp has low THC levels compared to marijuana specifically cultivated for personal psychoactive use. Whereas marijuana that can be smoked usually contains between five and ten percent THC, industrial hemp contains about one-tenth of that. In order to get a psychoactive effect, one would need to smoke ten or twelve hemp cigarettes over a very short period of time. 

To clarify, high-CBD cannabis oil is non-psychoactive and apparently even more beneficial than high-THC cannabis oil. Cannabidiol is another cannabinoid in the cannabis plant, like the more well-known psychoactive cannabinoid THC, with significant research suggesting neuroprotectant, anticancer, antidiabetic, anti-ischemic, antispasmodic, antipsychotic, and antibacterial properties, among others. Furthermore, cannabis oil is a type of extract from cannabis.

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In fact, not only will CBD not make you high, it has been proven to counteract the psychoactivity of THC. This property makes CBD highly useful as a medical treatment for a wide range of conditions. In terms of the CBD products you can buy, the amount of THC present varies from none at all in a pure CBD Isolate to a minimal amount (less than 0.3%) in a Full-Spectrum CBD product.
Of course, some patients don’t like or can’t ingest any form of CBD. However, that still leaves them with a wide range of products that will help them with their ailments. For example, a CBD cream or a CBD lotion is great for Lupus and arthritis patients. We can apply them directly to aching joints and other spots. Therefore, the necessary effects will be quicker.
There has been a dramatic rise in news attention to medicinal cannabis in 2013, with reports on CNN, ABC, CBS, and local publications about high-cannabidiol cannabis oil effectively controlling the symptoms of rare epileptic conditions like Dravet syndrome, Doose syndrome, infantile spasms, cortical dysplasia, and more. These diseases can cause hundreds to thousands of seizures a week, while also impairing development in a number of other ways. For families with children suffering from such conditions, the challenges are overwhelming.
Since pot increases alpha and theta sleep, it inhibits delta sleep, so it also inhibits growth hormone and klotho, the anti aging hormone. You may unknowingly be putting your body into a catabolic state speeding the destruction of your connective tissue and breaking down your connective tissue at a faster rate thus aging you faster, instead of building up stronger connective tissue which is your goal in getting healthy, normal, plus staying young.

So what exactly is Industrial Hemp? For most people, the first thought which comes to mind when someone mentions “industrial hemp” to them is – marijuana. But, industrial hemp is very different from marijuana, specifically in terms of the potential to get someone “high”, as it contains very small amounts of delta-9 tetrahydrocannabinol (THC – the psychoactive chemical).


so you can just make up a new plant because it don’t get the user high? Hemp is Cannabis. PERIOD. The Farm Bill and No amount of silly dialog can create a new botanical entry. Hemp IS Cannabis. Cannabis Ruderalis, native to Russia, also called ditch weed….may be imported as Hemp but it IS Cannabis Ruderalis. The semantic name calling game is kept in motion because it serves the desires of those that profit on the confusion. Bottomline, there is Cannabis. Some Cannabis can be used to fight disease. Oligodenroglioma (in my case) and some of it can be used to alter one’s outlook……but it’s all Cannabis. Grow it in South Carolina and call it Hemp, I say God bless you, bring it to my lab and it comes out as cannabis and it’s going to be called Cannabis. Disclaimer, while I do have oligodendroglioma, I do not personally have a lab ;). M.

Hemp seeds can be eaten raw, ground into hemp meal, sprouted or made into dried sprout powder. Hemp seeds can also be made into a liquid and used for baking or for beverages such as hemp milk and tisanes.[16] Hemp oil is cold-pressed from the seed and is high in unsaturated fatty acids.[17] The leaves of the hemp plant, while not as nutritional as the seeds, are edible and can be consumed raw as leafy vegetables in salads, and pressed to make juice.[18]
For this ranking update, we also looked at whether companies are providing third-party lab tests for their products post-formulation or if they’re just testing the source isolate or CBD extract which goes into all their products. Nobody can test every single bottle of product, but samples of each product can be tested for cannabinoid potency at a minimum.
CBD derived from marijuana is a different story, and the law varies from state to state. But as long as you’re using CBD oil that contains less than 0.3 percent THC, you have nothing to be concerned about anywhere in the United States. On the other hand, if you want to take your CBD on a trip outside the country, definitely look into local laws to avoid getting into awkward situations while you’re away.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.
Those who are looking for a unique and high-end form of cannabidiol products may want to look into Lord Jones. The products come in the form of tinctures, edibles, lotion, and even gumdrops. The formulas are also designed to provide users with relief from aches, pains, stress, and so much more. Better yet, the products come in unique and tantalizing flavors, including mango chili and sugarplum.
A crop for the future? With modern farming in big trouble, farmers are being paid not to cultivate their land, and food mountains are burnt in developed countries, while billions of people go hungry in developing countries. Hemp represents a lifeline crop for rural and hunger-prone areas, of particular value for its' versatility and organic nature. A famine-stricken village could clothe, house and feed themselves from one hemp field!
CBD has noted effects on many systems the brain uses to send signals to your body. One of these is the endocannabinoid system. When used, CBD can have beneficial effects on people who suffer neurological disorders. The research in this area is still new. However, there were many studies where CBD oil effects were tested on treating multiple sclerosis and epilepsy.

Hemp is not the same as marijuana. One really has nothing to do with the other. Hemp was made illegal back in the days when cotton was king in the south and southern cotton plantation owners did not want the competition. They lobbied for, and got a law against hemp being grown nationwide. It never had to do with drugs at that time, and still doesn’t. As always, money and government go hand in hand. Now, recently, South Carolina has legalized growing hemp again, which is the only state in 50 to do so. We will hope for more enlightened agri-business legislation across the nation, soon.
Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.
One of the many myths about the legalising of hemp cultivation is that those growing it will be able to hide the more potent marijuana amongst it. This isn’t viable as the intoxicating variety needs a great deal of space and is easy to pick. The other argument about high THC marijuana pollinating hemp and creating a higher THC hemp is null and void – this simply doesn’t happen. In fact, cross pollination will result in lower-THC marijuana.
Cannabis sativa L. subsp. sativa var. sativa is the variety grown for industrial use, while C. sativa subsp. indica generally has poor fiber quality and female buds from this variety are primarily used for recreational and medicinal purposes. The major differences between the two types of plants are the appearance, and the amount of Δ9-tetrahydrocannabinol (THC) secreted in a resinous mixture by epidermal hairs called glandular trichomes, although they can also be distinguished genetically.[61][63] Oilseed and fiber varieties of Cannabis approved for industrial hemp production produce only minute amounts of this psychoactive drug, not enough for any physical or psychological effects. Typically, hemp contains below 0.3% THC, while cultivars of Cannabis grown for medicinal or recreational use can contain anywhere from 2% to over 20%.[64]
Blessing and Haney agree that the current evidence suggests that CBD shows promise for helping to treat some illnesses. In June 2018, the Food and Drug Administration (FDA) approved the first cannabis-derived drug — Epidiolex, which contains purified CBD — to treat certain rare childhood seizure syndromes. However, much of the research on CBD is only in very early stages, and scientists still don’t know a lot about it — including whether it has negative long-term effects.
cbdMD is a brand that offers its customer base various products that offer clean and premium-grade cannabidiol. The products designed to work well from a wide range of users so that anyone can get the support they need. The products also come in a range of options, such as tinctures, capsules, and bath bombs. These options enable users to opt for what works best for them.
Here at Best Products, we’re certainly not newbies when it comes to the healing powers of CBD. We've generated a short list of the CBD products we love (hell ... you might even say we're a little CBD-obsessed). So we decided to harness our experience with said acronym and put together a definitive list of our current favorite CBD oil products — and yes, we weeded through some duds that did not quite make it on this list.
Wellness is much more than merely physical health, exercise or nutrition. It is the full integration of states of physical, mental, and spiritual well-being. The model used by our campus includes social, emotional, spiritual, environmental, occupational, intellectual and physical wellness. Each of these seven dimensions act and interact in a way that contributes to our own quality of life.
France is Europe's biggest producer (and the world's second largest producer) with 8,000 hectares (20,000 acres) cultivated.[87] 70–80% of the hemp fibre produced in 2003 was used for specialty pulp for cigarette papers and technical applications. About 15% was used in the automotive sector, and 5-6% was used for insulation mats. About 95% of hurds were used as animal bedding, while almost 5% was used in the building sector.[15] In 2010/2011, a total of 11,000 hectares (27,000 acres) was cultivated with hemp in the EU, a decline compared with previous year.[74][88]
It’s still very early in the days of cannabis research but there is a strong case for the therapeutic benefit of a less refined full spectrum hemp extract with more of the plant compounds intact. There are so many beneficial health possibilities waiting to be unlocked by further studying the combinations of these compounds found in hemp and cannabis.
The important thing is that you have to be SUPER careful when selecting CBD oils. Since the cannabis industry is not FDA-regulated, there have been dozens and dozens of companies trying to get away with selling very low quality (and even potentially toxic), “snake oils” that have been extracted using harsh chemical solvents like butane and hexane. Make sure you stay away from cheap products like these, as they could damage your health.

However, if it was sourced from actual marijuana (i.e. cannabis that contains more than 2% THC by volume), then it is technically illegal. Most of the best CBD oils for pain that you find in dispensaries in states like Colorado, California, and Washington (as well as other states where weed is legal) will have been extracted from marijuana plants — not industrial hemp plants. Unfortunately, this means that these products are not allowed to be sold online and shipped across state lines to “non-legal” states.
The United Kingdom and Germany resumed commercial production in the 1990s. British production is mostly used as bedding for horses; other uses are under development. Companies in Canada, the UK, the United States, and Germany, among many others, process hemp seed into a growing range of food products and cosmetics; many traditional growing countries still continue to produce textile-grade fibre.
so you can just make up a new plant because it don’t get the user high? Hemp is Cannabis. PERIOD. The Farm Bill and No amount of silly dialog can create a new botanical entry. Hemp IS Cannabis. Cannabis Ruderalis, native to Russia, also called ditch weed….may be imported as Hemp but it IS Cannabis Ruderalis. The semantic name calling game is kept in motion because it serves the desires of those that profit on the confusion. Bottomline, there is Cannabis. Some Cannabis can be used to fight disease. Oligodenroglioma (in my case) and some of it can be used to alter one’s outlook……but it’s all Cannabis. Grow it in South Carolina and call it Hemp, I say God bless you, bring it to my lab and it comes out as cannabis and it’s going to be called Cannabis. Disclaimer, while I do have oligodendroglioma, I do not personally have a lab ;). M.

Almost ten percent of people worldwide deal with acne. It’s a pretty common skin condition, even among adults. A few major factors can cause acne. Those are usually genetic makeup, bacterial infection, underlying skin inflammation, and sebum overproduction. Sebum is an oily secretion that lubricates our skin. It forms inside of sebaceous glands, which are under our skin.


   Industrial hemp has low THC levels compared to marijuana specifically cultivated for personal psychoactive use. Whereas marijuana that can be smoked usually contains between five and ten percent THC, industrial hemp contains about one-tenth of that. In order to get a psychoactive effect, one would need to smoke ten or twelve hemp cigarettes over a very short period of time. 


I’ve done a little research on the hemp and cannabis, and it looks to me like they’re both supposed to be medicine plants. From what I learned about the plants, they’ve been known to actually have multiple health benefits and even save lives of fourth stage cancer patients, sending the cancer into remission and therefore saving the patient lives. Banning this medicine plant has actually caused the deaths of many people who could have otherwise been saved by this plant. No wonder people are getting it other ways, I don’t blame them as long as it’s strictly for medical purposes. I even heard of a case where one child’s seizures were so bad they had to end up moving to Colorado as a last resort to save that little girl’s life by giving her cannabis because no other medicine worked for her.
Thank you for sharing your story. It is amazing the stories I have heard and the things you here the politicians debating over. The truth is out. They need to get over there guilty pride and pharmaceutical needs to be slapped down a few pegs. This is happening we just need to defend the corporations that back the oil, the pharma, any other corporation that doesn’t fight a health and balance model.
Green Roads takes the quality of their CBD products seriously. The brand aims at providing a healthier alternative to drugs. In that regard, all their products have the nod of a qualified pharmacist, further enabling you to buy in confidence. Green Roads offers CBD syrups, tinctures, edibles, topical creams, concentrates, and capsules, as well as coffee/teas, enhanced with cannabinoids.
Like with so many other natural products, no regulations have been put into place to test the potency or quality of these products. The labeling of these products is also not regulated the way they are for pharmaceutical drugs. Therefore, it is critically important to conduct research ahead of time and select the company that with provide you with the highest quality of pure CBD oil.
Other great products that are easily digested are the CBD capsules. An ongoing debate about whether CBD oil capsules are better than regular oil speaks volumes about how far we’ve come in the CBD business. Capsules and CBD pills often have a wider range of active molecules. Phytocannabinoids in capsules work together with other compounds to alleviate symptoms such as pain, nausea, anxiety, etc.

Buying online is less reliable still because there’s no regulation or standardization. What you see on the label may not be what you are getting. A 2017 study in JAMA found that of the 84 CBD products researchers bought online, 43% had more CBD than indicated, while 26% had less, and some had unexpected THC. “There’s a 75% chance of getting a product where the CBD is mislabeled,” says Marcu, one of the study’s coauthors.
In 2017, the cultivated area for hemp in the Prairie provinces include Saskatchewan with more than 56,000 acres (23,000 ha), Alberta with 45,000 acres (18,000 ha), and Manitoba with 30,000 acres (12,000 ha).[86] Canadian hemp is cultivated mostly for its food value as hulled hemp seeds, hemp oils and hemp protein powders, with only a small fraction devoted to production of hemp fiber used for construction and insulation.[86]
Other than the oil, CBDistillery also offers isolate powder. The powder is an excellent alternative you don’t like the idea of adding CBD oil into your drink or placing a couple of drops under your tongue. More specifically, the powder allows you to enjoy the benefits of CBD through vaping. You can also mix it with coconut oil and apply it topically on your body especially after strenuous activity.
Although cannabis can be used to make marijuana, CBD itself is non-psychoactive—meaning that it doesn’t get you high the way smoking or eating cannabis-related products containing THC (the plant's psychoactive compound) can. Still, there’s a lot doctors don’t know about CBD and its effects on the body, and a lot consumers should understand before trying it.
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