On a molecular level, all classes of cannabinoid are derived from the cannabinoid cannabigerol (CBG). Cannabinoids are changed from their original acid forms by decarboxylation through heat, light, or alkaline conditions, allowing them to interact fully with the endocannabinoid system. Learn more about all the cannabinoids found in our full spectrum hemp oil below:

There is some speculation that George Washington smoked the flower of the cannabis plant in order to achieve a recreational high ("Like all farmers, Washington probably sampled the quality and potency of what he grew, and he may have used this hemp to treat his chronic tooth aches"),[58] but there is no evidence in any of his writings that he grew hemp for anything other than industrial purposes. It is sometimes supposed that an excerpt from Washington's diary, which reads "Began to seperate [sic] the Male from the Female hemp at Do.&—rather too late" is evidence that he was trying to grow female plants for the THC found in the flowers. However, the editorial remark accompanying the diary states that "This may arise from their [the male] being coarser, and the stalks larger"[119] In subsequent days, he describes soaking the hemp[120] (to make the fibers usable) and harvesting the seeds,[121] suggesting that he was growing hemp for industrial purposes, not recreational.

The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide far better performance than any single compound alone, and that includes CBD. Here are a couple of examples of conditions that benefit from the entourage effect:
The 2014 US Farm Bill allows states that have passed their own industrial hemp legislation to grow industrial hemp for purposes of research and development. Several states — including Kentucky, Colorado, and Oregon — are already conducting hemp pilot projects. Many other states are currently pursuing similar legislation and programs. After many years of prohibition, American farmers are finally reacquainting themselves with industrial hemp.
The human body is made up of the Endogenous Cannabinoid System (ECS) which is responsible for the synaptic plasticity, neuromodulation, and development of the central nervous system and the peripheral system. The ECS consists of cannabinoid receptors among other substances that respond to the intake of different cannabinoid substances. The receptors can be found in various parts of the body. There are over 65 molecular targets of Cannabidiol in the human body. These target locations and receptors allow CBD oil to deliver its therapeutic benefits to the individual without any need to worry about any euphoric effect (caused by THC). For CBD to properly function, it is necessary that it is the important substance in any CBD based product; the higher the concentration of CBD in a product, the better your chances of enjoying its maximum benefits.
Francesca Fusco, MD, a dermatologist based in New York City, recently told Health that CBD oil is a rich source of fatty acids and other skin-healthy nutrients, and that it may improve hydration and minimize moisture loss. A few studies have also suggested that CBD oil may inhibit the growth of acne, although this hypothesis has only been tested in laboratory cell cultures—not in actual humans.
Two additional studies in this area were done using CBD oil. In the first one, 214 participants would take 0.9 to 2.3 grams of oil per 1 pound of body weight. CBD successfully reduced seizures by a median of 36.5%. The second study focused on children who suffered from Dravet syndrome. Dravet syndrome is a type of epilepsy that happens in early infancy. Normally high temperatures and fevers trigger it. The results of the second study showed that CBD oil reduced seizures significantly.

CBD for Life offers men and women the opportunity to opt from a wide range of beauty-based products and at the end of the day, it seems that its almost impossible to go wrong with skincare products. A few of the main formulas offered by the brand are rich in antioxidants and anti-inflammatory substances. The skincare formulas provide users with refreshing and quality support for men and women of all ages. Further, the company is owned and operated by women.
Industrial hemp farmers tend to aim to grow the plants up, not out as is the case with medicinal cannabis – and the taller, the better. This is because some of the great value of industrial hemp in fibre based applications is primarily in its stalk rather than leaves. Industrial hemp is grown at quite high density – another major difference to the cultivation of subsp. indica.

These are just a few specific instances that show how effective CBD oil can be, laying the groundwork for CBD oil being recognized as a justifiable medicine for a variety of ailments. As a result, many states are passing legislation rapidly allowing CBD oil to be used in numerous clinical studies as treatment plans. Research continues to back up it legitimacy and programs are being funded globally to continue the studies.

We have receptors for cannabinoids in the whole body, but the first type – CB1 – are very dense in the pain pathways of the brain, spine, and nerves. The second type – CB2 – is more important for the immune system but is also involved in inflammation. By gently acting on both pathways, our internal cannabinoids and CBD can balance both pain and inflammation [R+].
I have fibromylagia and was on a cocktail of 20 medicines. Last year I quit them all cold turkey one day. Was tired of the rate race, doctors visits, refills, cost, etc. I live in pain on a scale of 9 out of 10 most days and then had a car accident , was hit from behind and ended up with 3 herniated disks. I eat Ibuprofen like it’s candy some days and that has to stop. I ordered my first CBD oil today and am hoping it helps me. My son is a Vet and has been using these products for years and swears by them for his PTSD and war injuries.

What you gain from Full Spectrum CBD is called the “entourage effect.” Studies have suggested that CBD is most effective when it’s combined with other cannabinoids. Each cannabinoid has its own properties and confers its own benefits. Working together, a synergy is created that boosts the healing properties of CBD. Full spectrum CBD does, however, bring with it the sticky issue of THC. The government regulates concentration levels of THC at 0.3 percent, an amount which results in minimal psychoactivity.

The endocannabinoid system is spread throughout your brain and body, but primarily throughout your central nervous system. The interaction between cannabinoids and receptors is what produces effects like the regulation of mood, pain, appetite, inflammation, and memory. Plant-based cannabinoids, found in cannabis plants, also interact with the receptors (whimsically named CB1 and CB2) in the endocannabinoid system, and each affects your body in different ways. CBD and its infamous cousin THC are the 2 most well-known cannabinoids.


Cannabis sativa L. subsp. sativa var. sativa is the variety grown for industrial use, while C. sativa subsp. indica generally has poor fiber quality and female buds from this variety are primarily used for recreational and medicinal purposes. The major differences between the two types of plants are the appearance, and the amount of Δ9-tetrahydrocannabinol (THC) secreted in a resinous mixture by epidermal hairs called glandular trichomes, although they can also be distinguished genetically.[61][63] Oilseed and fiber varieties of Cannabis approved for industrial hemp production produce only minute amounts of this psychoactive drug, not enough for any physical or psychological effects. Typically, hemp contains below 0.3% THC, while cultivars of Cannabis grown for medicinal or recreational use can contain anywhere from 2% to over 20%.[64]

My name is Martha, My mom has dementia and Alzheimer’s disease, I took care for my mum. We were managing until these awful vigorous shaking seem to have took over her body, she can’t even hold a cup when it is at its worst and sleep is out of the question which leads to utter exhaustion. We were told that the medication she was on for her restless legs which was something totally different was making the shaking worse. But yet the shaking is part of the dementia. I was making research online on any possible solution that could help my mom and I came across how cannabis oil have helped a lot of people around the world to cure Alzheimer’s and Dementia. I was so happy and relief when I saw this and I knew there was hope for my mom to be well again. I contacted Medicinal Marijuana Resources to get the high quality THC cannabis oil for treatment and prescription on how to use the cannabis oil for treatment of Alzheimer’s and Dementia. My mom started using the cannabis oil for treatment as directed by Medicinal Marijuana Resources physician expert team. Now the Alzheimer’s and Dementia are gone and my mom is well, healthy and strong again


I always quote CBD oil as a “miracle cure”. The reason being when no other regular meds helped me there was CBD oil that helped me with my chronic back pain. Been using it for the past 2 years now. I haven’t tried the Kope CBD products but after reading this I’m curious. Rest all brands are well known to me. Let’s give Kope a try. Anyways, thanks for sharing this awesome information.
In the 1970s, President Nixon declared a “War on Drugs” and signed into law the Controlled Substances Act of 1970. This law established a set of banned drugs and created the Drug Enforcement Administration (DEA). It also unintentionally outlawed one of the world’s oldest domesticated crop, hemp. This not only led to the demise of hemp, but also an increased misconception of the plant.
NuLeaf Naturals CBD oil features a strong plant taste which is remarkably better than most oils. It is this flavor that makes NuLeaf oils an attractive option for most users. A closer look at independent reviews by customers reveals that this is excellent CBD oil for pain. Most users with chronic pain say they felt significantly better after a couple of doses of the oil, a factor attributed to the natural extraction process.

The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide far better performance than any single compound alone, and that includes CBD. Here are a couple of examples of conditions that benefit from the entourage effect:
Hemp-derived CBD oil products will not get you “high” since they contain little or no THC, the psychoactive ingredient in cannabis. They are also now federally legal in the United States following the signing of the 2018 Farm Bill. Of course more medical research studies are needed, but it’s expected that these products will continue to gain even more mainstream acceptance in the plant-based wellness communities.
Moreover, a patient survey conducted by Project CBD, declared that “…cannabis appears to be an effective pain management tool with few negative side effects.” The study went on to say that a “…significant decrease in opiate usage among elderly patients while taking medical cannabis [was observed during trial].” In short, it has been portrayed clearly numerous times through valid and well-publicized clinical studies that cannabis is a practical option in terms of efficient pain management.
Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.
So, if it’s not psychoactive, what exactly is hemp used for? Ever since the Neolithic Age when farmers in China first cultivated this plant, the use of hemp grew in order to fulfill many different needs people had through history. It is now used to make clothing, biofuels, foods, health products, body care products and even plastic composites. One source suggests that this “magical plant” is currently used to create more than 25 thousand different products – as many as petroleum. The U.S. hemp industry was estimated to be worth around 500 million USD in annual retail sales in 2012, and this number is quickly trending upward, according to Hemp Industries Association.
CBD oil can treat physiological problems. Repeated research shows that’s the oil makes a brilliant addition to a mental health treatment regimen for conditions such as anxiety. A study carried out the University of Sao Paulo suggests that CBD lowers subjective anxiety considerately by affecting the activity in paralimbic and limbic areas of the brain.
The seeds are sown with grain drills or other conventional seeding equipment to a depth of 1.27 to 2.54 cm. Greater seeding depths result in increased weed competition. Nitrogen should not be placed with the seed, but phosphate may be tolerated. The soil should have available 89 to 135 kg/ha of nitrogen, 46 kg/ha phosphorus, 67 kg/ha potassium, and 17 kg/ha sulfur. Organic fertilizers such as manure are one of the best methods of weed control.[60]
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The Medterra tincture utilizes an extraction process that effectively separates plant material while filtering unnatural substances, optimizing the CBD concentration. It has also undergone third-party testing to ensure quality and consistency. Just so you may know, this oil is odorless and tasteless, allowing you to take using various ways including adding it to your food or dropping it under your tongue.
Other great products that are easily digested are the CBD capsules. An ongoing debate about whether CBD oil capsules are better than regular oil speaks volumes about how far we’ve come in the CBD business. Capsules and CBD pills often have a wider range of active molecules. Phytocannabinoids in capsules work together with other compounds to alleviate symptoms such as pain, nausea, anxiety, etc.
The most abundant cannabinoid in hemp oil, making up over 90% of the cannabinoid content, cannabidiol or CBD is non-psychoactive and is the focus of the benefits from hemp oil. CBD has little affinity for CB1 or CB2 receptors, the main points of interaction for cannabinoids in the endocannabinoid system, and instead acts as an indirect antagonist of cannabinoid agonists, possibly allowing CBD to temper the high caused by THC. Our Gold Label RSHO™ is almost 25% CBD, making up most of oil’s weight. All other cannabinoids come in under 0.4% by weight.
Separation of hurd and bast fiber is known as decortication. Traditionally, hemp stalks would be water-retted first before the fibers were beaten off the inner hurd by hand, a process known as scutching. As mechanical technology evolved, separating the fiber from the core was accomplished by crushing rollers and brush rollers, or by hammer-milling, wherein a mechanical hammer mechanism beats the hemp against a screen until hurd, smaller bast fibers, and dust fall through the screen. After the Marijuana Tax Act was implemented in 1938, the technology for separating the fibers from the core remained "frozen in time". Recently, new high-speed kinematic decortication has come about, capable of separating hemp into three streams; bast fiber, hurd, and green microfiber.
The National Cancer Institute details several studies into the anti-tumor effects of CBD. One study in mice and rats suggest CBDs “may have a protective effect against the development of certain types of tumors.” CBDs may do this by inducing tumor cell death, inhibiting cancer cell growth, and by controlling and inhibiting the spread of cancer cells.
From health and disability insurance to employment and financial planning, members of the MS community have many needs to address. Making sure that you have the appropriate health insurance in place, finding ways to adjust your employment to suit your needs, learning how to apply for disability and other types of government assistance, and planning for the future financially, are all extremely helpful to keeping yourself on track. Please visit this section for more information.

Air-dried stem yields in Ontario have from 1998 and onward ranged from 2.6–14.0 tonnes of dry, retted stalks per hectare (1–5.5 t/ac) at 12% moisture. Yields in Kent County, have averaged 8.75 t/ha (3.5 t/ac). Northern Ontario crops averaged 6.1 t/ha (2.5 t/ac) in 1998. Statistic for the European Union for 2008 to 2010 say that the average yield of hemp straw has varied between 6.3 and 7.3 ton per ha.[73][74] Only a part of that is bast fiber. Around one tonne of bast fiber and 2–3 tonnes of core material can be decorticated from 3–4 tonnes of good-quality, dry-retted straw. For an annual yield of this level is it in Ontario recommended to add nitrogen (N):70–110 kg/ha, phosphate (P2O5): up to 80 kg/ha and potash (K2O): 40–90 kg/ha.[75] The average yield of dry hemp stalks in Europe was 6 ton/ha (2.4 ton/ac) in 2001 and 2002.[15]
In 2017, the cultivated area for hemp in the Prairie provinces include Saskatchewan with more than 56,000 acres (23,000 ha), Alberta with 45,000 acres (18,000 ha), and Manitoba with 30,000 acres (12,000 ha).[86] Canadian hemp is cultivated mostly for its food value as hulled hemp seeds, hemp oils and hemp protein powders, with only a small fraction devoted to production of hemp fiber used for construction and insulation.[86]

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.
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CBD derived from marijuana is a different story, and the law varies from state to state. But as long as you’re using CBD oil that contains less than 0.3 percent THC, you have nothing to be concerned about anywhere in the United States. On the other hand, if you want to take your CBD on a trip outside the country, definitely look into local laws to avoid getting into awkward situations while you’re away.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.

Blessing and Haney agree that the current evidence suggests that CBD shows promise for helping to treat some illnesses. In June 2018, the Food and Drug Administration (FDA) approved the first cannabis-derived drug — Epidiolex, which contains purified CBD — to treat certain rare childhood seizure syndromes. However, much of the research on CBD is only in very early stages, and scientists still don’t know a lot about it — including whether it has negative long-term effects.
Where marijuana can contain up to 30% THC, hemp typically contains only 0.3% or less THC. Hemp is naturally abundant in CBD, however, there is a difference between industrial hemp cultivated for commercial products and industrial hemp cultivated for CBD. Hemp that’s used for mainstream production wasn’t cultivated specifically for high levels of CBD.
Dosist has been in the cannabidiol industry for years, even before legalization. The brand provides users with precise doses and pens that allow for the dispersion of the substance. The dispensing mechanism also allows for accurate dosing so that users can start at whatever levels make them the most comfortable. There is also a range of blends and mixtures that users can choose from.
This is good news for the best CBD oil companies because the Farm Bill allows for the legal cultivation of industrial hemp, under certain circumstances, which can be a source of CBD. But CBD can also come from non-industrial hemp, namely the marijuana plant that most are more familiar with. Therefore, whether or not CBD oil for pain is legal can be a question of which “version” of the cannabis plant it was sourced from. If it was sourced from industrial hemp, (which contains less than 0.3% THC by volume), and it was cultivated under the Farm Bill, then it is legal.
In the 1970s, President Nixon declared a “War on Drugs” and signed into law the Controlled Substances Act of 1970. This law established a set of banned drugs and created the Drug Enforcement Administration (DEA). It also unintentionally outlawed one of the world’s oldest domesticated crop, hemp. This not only led to the demise of hemp, but also an increased misconception of the plant.
In 2017, the cultivated area for hemp in the Prairie provinces include Saskatchewan with more than 56,000 acres (23,000 ha), Alberta with 45,000 acres (18,000 ha), and Manitoba with 30,000 acres (12,000 ha).[86] Canadian hemp is cultivated mostly for its food value as hulled hemp seeds, hemp oils and hemp protein powders, with only a small fraction devoted to production of hemp fiber used for construction and insulation.[86]
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These are one of the most popular (and effective) choices for arthritis and other forms of localized pain and inflammation. Since the skin acts as an excellent semi-permeable membrane that “let’s the good stuff and keeps the bad stuff out,” rubbing CBD-infused creams into the affected area has proved to be quite effective in terms of both pain and inflammation reduction.
“I originally purchased 750mg and have used the entire bottle..I have noticed I am a lot calmer, less anxious. less headaches/sinus and have been sleeping better too..my joint pain has been less so have gone to the 750mg now to monitor pain levels and to really boost my own indocannibinoid system to the level I need to be to get the full healing effects…

The world-leading producer of hemp is China, which produces more than 70% of the world output. France ranks second with about a quarter of the world production. Smaller production occurs in the rest of Europe, Chile, and North Korea. Over 30 countries produce industrial hemp, including Australia, Austria, Canada, Chile, China, Denmark, Egypt, Finland, Germany, Greece,[70] Hungary, India, Italy, Japan, Korea, Netherlands, New Zealand, Poland, Portugal, Romania, Russia, Slovenia, Spain, Sweden, Switzerland, Thailand, Turkey, the United Kingdom and Ukraine.[71][72]
Read the label to find out the total milligrams of CBD in the entire bottle/product and how many milligrams are in one standard dose. CBD products vary in potency, with some containing more total CBD than others. Most products will have on the label exactly how much CBD is in one dropper or drop, so you’ll be able to tell exactly how much is in there.
“The political implications of that scheduling, from a research perspective, are limiting,” explains Sutton. “To my knowledge, of the thousands of academic and research bodies in the United States and Canada whom would be equipped to perform agricultural or medical research on this unique species, only around 40 have actual research licenses to study the plant in a limited context.”
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.

This is probably the most common question and perhaps the most difficult to answer. CBD is believed to interact with our own cannabinoid system, which means how we interact with CBD individually depends on our tolerance as well as our immunity. Therefore, one dose may work for one person and not the other. Surprisingly, it has nothing to do with weight, but once again our own system. This is why our physician recommends starting low and slow until you achieve the results you are looking for with the oil.

Just one last thing before we explain the benefits of full spectrum CBD oil; it’s important to understand that CBD from cannabis is only legal in medical or recreational states, while CBD hemp oil is legal in all 50 states under the 2014 US Farm Bill. While it may not be able to treat all conditions, it has been known to assist with a variety of medical conditions including anxiety, depression and acute pain.
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