Dr. Devinsky’s research, which was recently published in The New England Journal of Medicine, is beginning to provide that much-needed data in the field of epilepsy research. In a landmark multinational randomized double-blind study for a treatment-resistant form of the condition, subjects taking an oral solution of 20 mg CBD per kilogram of body weight for 14 weeks, along with standard treatment, experienced a 42 percent reduction in drop seizures (the muscles go limp). Those taking a 10 mg CBD per kilogram of body weight saw a 37 percent decrease; patients who got a placebo saw a 17.2 percent decrease. The mechanism hasn’t quite been worked out yet, Dr. Devinsky says, though there’s some evidence that a receptor known as GPR55 may be critical for the anti-seizure effect.
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THC-dominant edibles (like chocolates) can carry an even higher risk. “It can take one or two hours to feel an effect from ingestion as opposed to a few seconds from inhalation,” says Dr. Bonn-Miller. “This makes titration very difficult.” Add to that, an edible is made to taste good. So you can easily eat more than you should in the course of a few minutes—and end up feeling negative effects hours later.
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases. But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
So, many of CBD's popularized benefits aren't well-proven. But are there any harms in trying CBD-containing products? In a word, yes. While any reported side effects from CBD alone are minor (think dry mouth and dizziness), they can be serious if the CBD products interact with other medications, experts say. Since CBD is metabolized by the same enzyme in the liver that metabolizes many conventional medicines and supplements, the chemical can cause the levels of other drugs in the system to rise; in some cases – like for those taking a drug to prevent their bodies from rejecting a donor organ – to a deadly level, Tishler says.
Extracting CBD from the hemp plant is just one part of the process for making CBD hemp oil. Extracted CBD oil is less than palatable. If the consumer’s desire is to make CBD oil part of their everyday routine, producers try to make the oil at least a little bit tasty. Also, consumers require a choice when it comes to the product’s potency, or the strength of the CBD oil-based product. Producers then need to dilute the raw CBD oil to accommodate their needs.
Officially, marijuana is deemed as Schedule I herbal substance by the U.S. Drug Enforcement Administration, meaning the drug offers "no currently accepted medical use and a high potential for abuse," according to the federal government. That categorization was adjusted after the passage of the 2018 Farm Bill, which included a provision that separated hemp from marijuana, as noted in the Controlled Subject Act.
That being said, though, CBD isolate still has a very relevant place in the cannabis market. A lot of people, for instance, use it to concoct their own personal daily CBD remedies – they mix the pure powder with oil, or they add it into their coffee, or they make edibles out of it. Since it comes in an easily-measurable powder, it’s a great option for those individuals who are trying to calculate exact personal dosages of CBD medication by the milligram.
Before we directly compare the both, let’s break down what each is. Full spectrum CBD oil comes with all the cannabinoids present in hemp. If you see full spectrum hemp CBD oil for sale, it’ll include many cannabis compounds such as Cannabicycol (CBL), Tetrahydrocannabivarin (THCV), Cannabinol (CBN), Cannabichromevarinic Acid (CBCVA) and more. It also contains a very small amount of THC, (.3%, as is legally allowed).
These studies conclude that “the higher efficiency of plant extract can be explained by additive or synergistic interactions between CBD, terpenes, and the minor phytocannabinoids or non-cannabinoids presented in the extracts. …because other phytocannabinoids, including Tetrahydrocannabivarin, Cannabigerol and Cannabichromene, as well as mono- and sesquiterpenes, exert additional effects of therapeutic interest and the therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse effects.”
At this point in time we have multiple states selling medical marijuana and other states looking to jump on board where there are other states that seemingly will never be open to the idea of legal cannabis. The decision on cannabidiol isn’t getting any easier, and company propaganda isn’t helping any. I think it’s obvious after talking to people from both sides of the spectrum that this choice is not cut and dry, and instead is something that you, the cannabidiol buyer, has to educate yourself on so you can make a fully informed decision.  While there are still choices for you to make, I now hope you have the information and facts to make an educated choice.
Whole plant CBD oils can be made in a variety of ways. The “original” CBD oil was created by Rick Simpson. This method requires you to soak the plant material in a solvent, such as grain alcohol. Once the material soaks, the remaining liquid is full of CBD (and other cannabinoids), you evaporate the solvent and the remaining oil is ready for consumption.
The key difference between hemp and marijuana is that hemp contains practically zero THC. In fact, in order to be classified as hemp, a cannabis plant must contain less than 0.3% THC by volume. This is really important because it’s actually the reason why hemp products are legal to buy, sell, and ship. If they don’t get you high, then why would they be illegal?
Quality is a particular concern, because cannabis plants easily soak up heavy metals from pesticides and other contaminants, Marcu says. If you are buying online, look for a company that documents how it tests its products. (If the website doesn’t indicate this, call and ask.) “Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
Blood pressure. Scientists say that CBD can also aid the lowering of blood pressure in humans, mainly by reducing the body's systolic pressure in the arteries as the human heart pumps blood. By taking a moderate dosage of CBD oil, some health experts say, an individual can improve blood flow, lower the heart rate and reduce the anxiety the stress often found in patients with high blood pressure.

At this point in time we have multiple states selling medical marijuana and other states looking to jump on board where there are other states that seemingly will never be open to the idea of legal cannabis. The decision on cannabidiol isn’t getting any easier, and company propaganda isn’t helping any. I think it’s obvious after talking to people from both sides of the spectrum that this choice is not cut and dry, and instead is something that you, the cannabidiol buyer, has to educate yourself on so you can make a fully informed decision.  While there are still choices for you to make, I now hope you have the information and facts to make an educated choice.
While there is much debate on which form is better, this 2015 study leans in favor of full spectrum CBD oil products. There are many that believe that other cannabinoids, THC especially, are necessary to take full advantage of what cannabis has to offer. Ultimately, however, we are all different and it comes down to the individual user and their needs. If drug testing is a concern, you’re encouraged to seek out CBD isolate products (or terpsolates) or broad spectrum products instead of full spectrum.
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