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The plants are cultivated and then sent for extraction. Some CBD oil-based products come from whole plant extracts. Others are derived from isolates. Whole plant extraction is self-explanatory. The entire plant is part of the process. Those in the medical communities prefer this method. They believe that a broader spectrum of cannabinoids yields during whole plant extraction. According to medical specialists, capturing the entire cannabinoid spectrum stimulates the endocannabinoid system. They call this the “entourage effect.”
And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
Another concern is about medications with which CBD might interact. This won’t be an issue with most drugs, says Sunil Kumar Aggarwal, M.D., Ph.D., a palliative medicine physician and scientist who studies cannabis and integrates it into his Seattle medical practice. The exceptions are blood thinners, IV antibiotics, and other drugs whose exact dosing is crucial and must be monitored closely, he says. (Of course, if you have a health problem, talk to your doctor before using CBD, and never take it instead of seeing your physician for a serious condition.)
Full spectrum CBD also contains a variety of essential vitamins, minerals, fatty acids, protein, chlorophyll, terpenes, flavonoids, and fiber. When referring to CBD in the hemp plant, it’s important to understand that hemp contains a large number of cannabinoids (in trace amounts), but the main compound is cannabidiolic acid (CBDa). As CBDa is more abundant in the hemp plant, firms must decarboxylate the oil. This process heats the oil and changes CBDa into CBD.
THC-dominant edibles (like chocolates) can carry an even higher risk. “It can take one or two hours to feel an effect from ingestion as opposed to a few seconds from inhalation,” says Dr. Bonn-Miller. “This makes titration very difficult.” Add to that, an edible is made to taste good. So you can easily eat more than you should in the course of a few minutes—and end up feeling negative effects hours later.
Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.
The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.
Supercritical CO2 extraction is also the key to understanding more cannabinoids in cannabis like Cannabichromene (CBC) and cannabicitran (CBT) and how they interact with each other (called the Entourage effect). This can lead to increased understanding of marijuana in the medical field, and will also allow growers to come up with more effective, new and exciting strains.
Blood pressure. Scientists say that CBD can also aid the lowering of blood pressure in humans, mainly by reducing the body's systolic pressure in the arteries as the human heart pumps blood. By taking a moderate dosage of CBD oil, some health experts say, an individual can improve blood flow, lower the heart rate and reduce the anxiety the stress often found in patients with high blood pressure.
Only high grade CBD oil is used for manufacture of e-liquid or vaping oil that is used in electronic cigarettes. The vaping liquids used in both disposable and non disposable electronic cigarettes are made as compounds with CBD oil, alkaline e-liquids, vegetable glycerin, flavors and also nicotine to give smokers the feeling of a real cigarette. But buyers of e-liquid refills should read the details of ingredients on the bottle of e-liquid to ensure that they are not using synthetic ingredients like propylene glycol or formaldehyde.
The appeal? Proponents claim CBD can help ease pain, anxiety, depression and stress, boost focus and productivity, improve the immune system, reduce inflammation and more. And – unlike its psychoactive cousin THC – CBD, they say, is harmless, legal and can't get you high. "The known is it's good for you, it helps a lot of people and a lot of things, and you can't hurt yourself," says Phil Asquith, a farmer and producer of extra-virgin olive oil in California, who founded one of the first companies in the CBD space. "The unknown is all the details."
In response to the FDA’s historic decision, the Drug Enforcement Administration (DEA) announced in September 2018 that it had removed Epidiolex from Schedule I classification, a category reserved for dangerous drugs with no medical value. Henceforth, Epidiolex would be considered a Schedule V drug, the least dangerous designation under the Controlled Substances Act.
‘I recommend starting with a low dose and slowly building up over a few weeks, to find the dose that works best for you,’ agrees Dr Brewer. ‘For example, start with Healthspan High Strength CBD Oil 6.4mg Capsules, taking one to three daily. Then, if needed, move up to Super Strength CBD 15mg Capsules, taking one to two daily. CBD is not psychoactive and is not addictive. I prefer capsules, as CBD drops have a strong taste, although filter-clear peppermint flavoured drops are available.’
Cannabigerol is known as the stem cell cannabinoid for its role as a precursor to other cannabinoids found in hemp and marijuana. Previously overlooked as a significant cannabinoid, the role of CBG is becoming better understood, and companies like Medical Marijuana, Inc.’s AXIM® Biotechnologies are starting to research its potential. Because most CBG is transformed into other cannabinoids like CBD or THC by the cannabis plant, natural CBG levels are low in most processed cannabis plants.
There are a number of possible side effects to using CBD oil, such as fatigue, dry mouth, lightheadedness, hypotension, and impaired motor functions. However, when used in moderate amounts, most people do not experience these side effects, and none of them are known for being fatal or particularly dangerous. More than 20,000 studies have been done in the past 15 years on cannabis, hemp, and cannabinoids, and the results have been overwhelmingly supportive of the therapeutic potential and viability of CBD oil. That being said, some people should be cautious before using this powerful oil.
So Herrera, who's experienced her own share of pain due to a shoulder injury followed by a bout of Lyme disease, went to a local herb shop and bought a vial of the oil, which, by some definitions, is legal in all states if it doesn't contain more than 0.3 percent THC – the psychoactive component of cannabis. She began putting seven to nine drops under her tongue first thing most mornings – and was startled by the results. "It's changed my pain level, my anxiety level and my stress level," says Herrera, who already practiced yoga, meditated regularly, ate a healthy diet and tried conventional medical treatments for pain and mobility. "It was shocking," she says, because she thought her patients' reports were due to the placebo effect. "Right now," she adds, "I feel pretty amazing."