‘CBD has proven anti-anxiety effects and may be helpful in depression, based on anecdotal reports,’ says Dr Gordon. ‘I use high CBD prescription cannabis medicine products as part of a mental health protocol with my patients suffering with anxiety and depression. The antidepressant effects of CBD have been shown in animal models, but we now need large, depression-specific studies in humans as the next step.’
There are a number of possible side effects to using CBD oil, such as fatigue, dry mouth, lightheadedness, hypotension, and impaired motor functions. However, when used in moderate amounts, most people do not experience these side effects, and none of them are known for being fatal or particularly dangerous. More than 20,000 studies have been done in the past 15 years on cannabis, hemp, and cannabinoids, and the results have been overwhelmingly supportive of the therapeutic potential and viability of CBD oil. That being said, some people should be cautious before using this powerful oil.
For applications where pure CBD isn’t required, full spectrum CBD oil is the better alternative, as it provides patients the ancillary benefits associated with the many other cannabis compounds. However, important to note, is the issue of what medical conditions are best treated by either pure or full spectrum CBD oil, given the research is in its infancy. 
The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide far better performance than any single compound alone, and that includes CBD. Here are a couple of examples of conditions that benefit from the entourage effect:

ISA HERRERA HEARD IT from her patients first. "I have less pain." "I'm having less anxiety." "My menstrual cramps are less intense," they told the New York City physical therapist about taking CBD oil, a product containing cannabidiol, one of many chemicals found in the cannabis plant. "I was like, 'I need to find out more about this,'" recalls Herrera, who specializes in integrative pelvic floor therapies.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.
By formulating our products with pure, full-spectrum hemp oil, we ensure that all the cannabinoids naturally found in the plant are in the hemp oil you buy from us. This also allows the cannabinoids to interact with the endocannabinoid system in what has become known as the entourage effect: when all the ingredients in hemp oil, including the terpenes, vitamins, and range of cannabinoids are allowed to work with the body naturally, as they would in the natural plant.

Given CBD’s reputation as a popular, artisanal remedy, one would think that Epidiolex would command a lot of “off label” attention. After all, physicians often prescribe pharmaceuticals off label to treat conditions that were not the actual focus of clinical trials. But the costly price tag for Epidiolex (more than $30,000 annually) precludes off label prescribing as well as affordable access for tens of millions of Americans without health insurance.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.
Another concern is about medications with which CBD might interact. This won’t be an issue with most drugs, says Sunil Kumar Aggarwal, M.D., Ph.D., a palliative medicine physician and scientist who studies cannabis and integrates it into his Seattle medical practice. The exceptions are blood thinners, IV antibiotics, and other drugs whose exact dosing is crucial and must be monitored closely, he says. (Of course, if you have a health problem, talk to your doctor before using CBD, and never take it instead of seeing your physician for a serious condition.)
exhaustion and pain that kept her on the couch much of the day. The 58-year-old Seattle speech coach didn’t want to take opioid pain-killers, but Tylenol wasn’t helping enough. Roth was intrigued when women in her online chat group enthused about a cannabis-derived oil called cannabidiol (CBD) that they said relieved pain without making them high. So Roth, who hadn’t smoked weed since college but lived in a state where cannabis was legal, walked into a dispensary and bought a CBD tincture. “Within a few hours of placing the drops in my mouth, the malaise and achiness that had plagued me for weeks lifted and became much more manageable,” she says. She took the drops several times a day and in a few weeks was back to her regular life.

Unfortunately, you don’t. Even though more than half of all U.S. states now allow marijuana for medicinal purposes—and nine of those, plus Washington DC, allow it for recreational use—the Drug Enforcement Agency still views CBD as a banned substance and therefore doesn’t regulate it (since, in the eyes of the law, CBD shouldn’t be on the market). “I can start a company, put oil in a jar and sell it as CBD oil,” says McLaughlin—and no one has to vouch that what’s in there is for real. You have only the manufacturers word for it.
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Unfortunately, you don’t. Even though more than half of all U.S. states now allow marijuana for medicinal purposes—and nine of those, plus Washington DC, allow it for recreational use—the Drug Enforcement Agency still views CBD as a banned substance and therefore doesn’t regulate it (since, in the eyes of the law, CBD shouldn’t be on the market). “I can start a company, put oil in a jar and sell it as CBD oil,” says McLaughlin—and no one has to vouch that what’s in there is for real. You have only the manufacturers word for it.

Along with its better-known counterpart, THC (delta-9-tetrahydrocannabinol, the chemical that produces the marijuana high), CBD is one of more than 400 compounds found in the oils of cannabis plant species, which include marijuana and hemp. Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, Ph.D., director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.

While it is clear that full spectrum CBD may be more effective than isolate CBD, even at lower dosages, it may have some drawbacks. Full spectrum vs regular CBD comes down to this drawback for many people. If full spectrum CBD oil is not an option for you due to your obligations or lifestyle, this can help you make your decision more easily for sure.
Full spectrum CBD, like hemp oil, contains every cannabinoid present in the cannabis plant. This means cannabidiol, cannabicyclol, tetrahydrocannabivarin, and cannbichromevinaric acid, to name a few. In full spectrum CBD oil, there is nothing held back or left out. These mixed together compliment each other and produce an entourage effect. This effect is good for the health of the user because the individual is taking all of the properties of all the terpenes and cannabinoid mixed together. All of these combined properties make the user absorbent of more effective effect and treatment. The treatment is very much beneficial for the health of the user hence that is why many users consider the full spectrum CBD far better than Isolate is CBD. Most products of CBD are from full-spectrum CBD.
Agreed. Full Spectrum could legally have .03% or less of THC which will cause you to fail a drug test. That is why I prefer Mezza Luna CBD Broad spectrum. It has 0.0% THC and the test to prove it. Full Disclosure I also work for the company. But I was a client first and the other difference is that there is no plant material in it. It is super clear gold in color and taste just like a light cooking oil. No need to guzzle a bottle of water after it.
Quality is a particular concern, because cannabis plants easily soak up heavy metals from pesticides and other contaminants, Marcu says. If you are buying online, look for a company that documents how it tests its products. (If the website doesn’t indicate this, call and ask.) “Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
Supercritical CO2 extraction is also the key to understanding more cannabinoids in cannabis like Cannabichromene (CBC) and cannabicitran (CBT) and how they interact with each other (called the Entourage effect). This can lead to increased understanding of marijuana in the medical field, and will also allow growers to come up with more effective, new and exciting strains.
In terms of how CBD is extracted from the cannabis plant, there a few different techniques that can be used. The most popular used to be by running harsh chemicals like butane (lighter fluid) or hexane over the raw plant material, but people quickly found out that this resulted in trace amounts of carcinogenic compounds (like formaldehyde) being left over in the end product. Not good.

‘The media has no doubt helped drive this popularity,’ says Dr Sarah Brewer, medical director at Healthspan. ‘However, the main drive is because people who take it experience the benefits very quickly, and “word of mouth” is a powerful thing. CBD oil also has such a wide range of benefits, reducing anxiety, promoting relaxation, ensuring a good night’s sleep, reducing pain perception and improving general feelings of wellbeing. It therefore appeals to a wide range of people.’


When extracting a pure botanical oil from hemp, a solvent is passed through the plant material, pulling the compound rich oil from the plant. The solvent is then removed in a purging process, leaving behind a concentrated oil. When extracting from hemp, the oil can next be formulated into finished products or further refined and purified into a number of forms, including a golden dewaxed concentrate or crystallized CBD isolate.
CBD oil took the world by storm a few years ago when Dr. Sanjay Gupta investigated the cannabinoid’s ability to treat children with epilepsy. Initially, CBD oil was viewed as a medicine for the critically ill, but its appeal to the general public is surging. With few regulations, the CBD oil market is congested with questionable products. As a consumer of CBD oils, it is essential for you to know how they are made.

There's also the question of CBD's legality – something that's a lot grayer than the black-and-white picture most companies paint. The U.S. Drug Enforcement Administration considers CBD, like all cannabinoids, a schedule 1 drug. That means it's just as illegal as heroin and ecstasy. Meanwhile, hemp – a variety of the cannabis plant regulated by the U.S. Department of Agriculture – is legal , so long as its THC content is negligibly low. But because the agriculture department doesn't test for CBD – only THC – in hemp, more companies are getting away with selling products they say contain CBD, says Sara Jane Ward, an assistant professor of pharmacology at the Temple University Lewis Katz School of Medicine who's been studying CBD in rodent models for more than 10 years. Needless to say, the legality of CBD is "very confusing and very gray," she says.
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