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'If the Patient Information Leaflet that comes with your medication says to avoid grapefruit juice, for instance, then do not take CBD, as the same type of interaction can affect circulating blood levels of your medicine. Even if the leaflet does not mention grapefruit juice, you should still check with your doctor before taking CBD. You should also not take CBD if you are pregnant or breastfeeding.’
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The appeal? Proponents claim CBD can help ease pain, anxiety, depression and stress, boost focus and productivity, improve the immune system, reduce inflammation and more. And – unlike its psychoactive cousin THC – CBD, they say, is harmless, legal and can't get you high. "The known is it's good for you, it helps a lot of people and a lot of things, and you can't hurt yourself," says Phil Asquith, a farmer and producer of extra-virgin olive oil in California, who founded one of the first companies in the CBD space. "The unknown is all the details."
exhaustion and pain that kept her on the couch much of the day. The 58-year-old Seattle speech coach didn’t want to take opioid pain-killers, but Tylenol wasn’t helping enough. Roth was intrigued when women in her online chat group enthused about a cannabis-derived oil called cannabidiol (CBD) that they said relieved pain without making them high. So Roth, who hadn’t smoked weed since college but lived in a state where cannabis was legal, walked into a dispensary and bought a CBD tincture. “Within a few hours of placing the drops in my mouth, the malaise and achiness that had plagued me for weeks lifted and became much more manageable,” she says. She took the drops several times a day and in a few weeks was back to her regular life.
Sarah Jorczyk is an advocate for CBD products and one of the Administrators of the CBD Oil Users Group on Facebook. She strives to educate the public, and promotes the use of safe products while helping others throughout their CBD journey. You can also find a variety of her content, including reviews and educational videos, on the group's youtube page.
Not much, as far as humans are concerned—at least not yet. The vast majority of studies have been on animals, as of yet, and there are few high-quality studies on humans. Even the oil’s effect on pain—something that CBD oil is popularly used for—isn’t proven. “The studies available are small or not well designed,” says Dr. Devinsky. “There’s a lot of religion out there, but not a lot of data.”
No one’s really sure: “It’s astonishing that there’s still no real consensus on how CBD works,” says McLaughlin. “One thing we do know is that it doesn’t work through the same receptors as THC, and, in fact, seems to have the opposite effect.” THC mainly binds to a certain type of receptor (known as CB1) in the brain. But with CBD, he says, “there seems to be a lot of complex targets”—which means CBD may affect multiple pathways throughout the body.
Everything you need to know about marijuana (cannabis) Marijuana, or cannabis, is the most commonly used illicit drug in the world. It alters the mood and affects nearly every organ in the body. With at least 120 active compounds, marijuana may have health benefits as well as risks. We describe these, addiction, and withdrawal. Learn more about cannabis here. Read now