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Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
Tetrahydrocannabinol is the most abundant cannabinoid in most medical and recreational marijuana strains. However, in hemp THC is a minor constituent and appears only in trace amounts under 0.3% by dry weight, as required by the U.S. government for hemp products. THC mimics the action of anandamide, a neurotransmitter naturally produced in the human body, and binds to CB1 receptors in the endocannabinoid system found mostly in the brain. The extremely low levels of THC in hemp make hemp oil non-psychoactive and safe for all ages to use.
Supercritical CO2 extraction is also the key to understanding more cannabinoids in cannabis like Cannabichromene (CBC) and cannabicitran (CBT) and how they interact with each other (called the Entourage effect). This can lead to increased understanding of marijuana in the medical field, and will also allow growers to come up with more effective, new and exciting strains.
You can also mix this full-spectrum hemp CBD oil into your favorite beverage. Keep the Bluebird Botanicals CBD oil refrigerated, and shake well before use. While most people find their sweet spot at around 15 drops, your serving size may vary according to your metabolism. Since there are no side-effects and there is no danger of overdosing, you can safely tweak your serving size to find the perfect amount of CBD your body needs. Below you’ll find CBD concentration conversions according to Bluebird Botanicals:
The most abundant cannabinoid in hemp oil, making up over 90% of the cannabinoid content, cannabidiol or CBD is non-psychoactive and is the focus of the benefits from hemp oil. CBD has little affinity for CB1 or CB2 receptors, the main points of interaction for cannabinoids in the endocannabinoid system, and instead acts as an indirect antagonist of cannabinoid agonists, possibly allowing CBD to temper the high caused by THC. Our Gold Label RSHO™ is almost 25% CBD, making up most of oil’s weight. All other cannabinoids come in under 0.4% by weight.
That being said, though, CBD isolate still has a very relevant place in the cannabis market. A lot of people, for instance, use it to concoct their own personal daily CBD remedies – they mix the pure powder with oil, or they add it into their coffee, or they make edibles out of it. Since it comes in an easily-measurable powder, it’s a great option for those individuals who are trying to calculate exact personal dosages of CBD medication by the milligram.
Herrera and her patients aren't the only ones doling out rave reviews for CBD oil, which can be found online and in cannabis dispensaries, as well as in some grocery stores and even as an optional add-in alongside protein powder at your local juice chain. The oil has been riding the coattails of the growing legal cannabis industry, with one industry expert, Matt Karnes, telling Forbes in 2016 that he expected CBD products to become an almost $3 billion market by 2021.
No one’s really sure: “It’s astonishing that there’s still no real consensus on how CBD works,” says McLaughlin. “One thing we do know is that it doesn’t work through the same receptors as THC, and, in fact, seems to have the opposite effect.” THC mainly binds to a certain type of receptor (known as CB1) in the brain. But with CBD, he says, “there seems to be a lot of complex targets”—which means CBD may affect multiple pathways throughout the body.