Only high grade CBD oil is used for manufacture of e-liquid or vaping oil that is used in electronic cigarettes.  The vaping liquids used in both disposable and non disposable electronic cigarettes are made as compounds with CBD oil, alkaline e-liquids, vegetable glycerin, flavors and also nicotine to give smokers the feeling of a real cigarette. But buyers of e-liquid refills should read the details of ingredients on the bottle of e-liquid to ensure that they are not using synthetic ingredients like propylene glycol or formaldehyde.
Supercritical CO2 extraction is also the key to understanding more cannabinoids in cannabis like Cannabichromene (CBC) and cannabicitran (CBT) and how they interact with each other (called the Entourage effect). This can lead to increased understanding of marijuana in the medical field, and will also allow growers to come up with more effective, new and exciting strains.
For applications where pure CBD isn’t required, full spectrum CBD oil is the better alternative, as it provides patients the ancillary benefits associated with the many other cannabis compounds. However, important to note, is the issue of what medical conditions are best treated by either pure or full spectrum CBD oil, given the research is in its infancy. 
We have all seen the recent news articles showcasing CBD oil and many of us would like to get involved... but where do you start?  In the event you didn’t already know, there are two sources for CBD oil and other CBD/Cannabidiol products: 1.)  Hemp CBD products made from industrial hemp and 2.) Medical marijuana CBD products derived from medical marijuana.  One is available widely online from sites like DiscoverCBD.com and the other is available at medical marijuana dispensaries across the US in states where medical marijuana is legal.
“There’s no oversight,” says Marcel Bonn-Miller, PhD, adjunct assistant professor of Psychology in Psychiatry at the University of Pennsylvania and author of the JAMA article. Beyond the label, he adds, “There’s no consistency. You know that every Hershey’s bar you buy and every Coke you buy will be exactly the same. But that’s not the case with the majority of CBD products. It’s not unexpected to see variability within a given brand.” This means that you may notice improvements the first time you buy and try a particular product, but none the next.
Cannabinol results from the degradation of THC. There is little of it in the fresh plant, but decarboxylation often raises the amount of CBN in the plant as an effect. CBN is only mildly psychoactive and has a higher affinity for the CB2 receptor than the CB1 receptor, linking CBN to the body’s immune system. In hemp oil, CBN is present in levels of 0.2% or lower.
And, if you do luck out and get a tincture truly containing CBD, you'll likely dish out $200 or so to take 10 to 40 milligrams daily. Since research participants take closer to 1,000 milligrams a day, it's hard to imagine a benefit without drinking the whole (expensive, calorie-dense) bottle, Tishler says. "Most people will adjust their doses based on what they're comfortable spending," Asquith says.
New name. New label. Same great formula. Bluebird Botanicals: Classic Hemp Blend contains 250 mg of concentrated CBD in a 1 oz bottle and twice that in a 2 oz bottle. Powerful, potent and tasty, this simple-to-use CBD oil soothes the senses and enhances overall wellness. The virgin hemp seed oil that holds it all together is rich in antioxidants and essential fatty acids, and its wholesome and hempy taste is perfectly balanced. This CBD-rich hemp oil blends seamlessly with hemp seed oil to create a mouth-watering, earthy flavor that goes exceptionally well with hot beverages, as well as cold drinks and a variety of foods. The rosemary extract used in this full-spectrum recipe acts as a natural preservative to ensure freshness. The end result will delight even the most discerning CBD oil fans.

Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, M.D., clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger. This is why Amanda Oliver, 31, a career consultant in Charleston, SC, pops a CBD gummy bear each night before bed. “I used to lie there tossing and turning as my mind raced from work projects to whether I had set the home alarm,” Oliver says. One piece of candy with 15 mg of CBD is enough to shut off her brain and facilitate sleep. She also swears by the CBD oil she takes at the height of her period, which she says quells her debilitating cramps.


A study published by David Cheng, Postdoctoral Scientist, Neuroscience Research, University of New South Wales, NSW, Australia, says that CBD has a potential as a preventive measure against symptoms of Alzheimer’s. This presents yet another exciting development for medical researchers, given the persistent challenges to finding effective solutions for this condition.

Since our beginning, Medical Marijuana, Inc. has been striving to bring the health benefits of cannabinoids to the lives of as many people as possible through cannabinoid hemp oil supplements. With our knowledge of cannabinoids and the endocannabinoid system just scratching the surface of what’s possible, there is plenty of potential to find new uses for the myriad of cannabinoids available to us.
Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.

Yes: CBD extracts can’t always be trusted. A 2017 JAMA paper reported that almost 70 percent of all CBD products sold online do not contain the amount of CBD stated on the label. Of the 84 products bought from 31 different companies, 42 percent contained a higher concentration of CBD oil than the label claimed, and 26 percent of the products contained less than the label claimed. The remainder of products contained the labeled amount—give or take 10 percent.
So Herrera, who's experienced her own share of pain due to a shoulder injury followed by a bout of Lyme disease, went to a local herb shop and bought a vial of the oil, which, by some definitions, is legal in all states if it doesn't contain more than 0.3 percent THC – the psychoactive component of cannabis. She began putting seven to nine drops under her tongue first thing most mornings – and was startled by the results. "It's changed my pain level, my anxiety level and my stress level," says Herrera, who already practiced yoga, meditated regularly, ate a healthy diet and tried conventional medical treatments for pain and mobility. "It was shocking," she says, because she thought her patients' reports were due to the placebo effect. "Right now," she adds, "I feel pretty amazing."
The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide far better performance than any single compound alone, and that includes CBD. Here are a couple of examples of conditions that benefit from the entourage effect:

The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide far better performance than any single compound alone, and that includes CBD. Here are a couple of examples of conditions that benefit from the entourage effect:

Sarah Jorczyk is an advocate for CBD products and one of the Administrators of the CBD Oil Users Group on Facebook. She strives to educate the public, and promotes the use of safe products while helping others throughout their CBD journey. You can also find a variety of her content, including reviews and educational videos, on the group's youtube page.
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Full spectrum CBD includes hundreds of active compounds, each in varying amounts and potencies, each with their own subtle action. The Entourage Effect predicts that some of these compounds can work in concert with each other to produce larger effects than they could individually, and that some compounds support the actions of others or even help render active compounds that normally wouldn’t be.

Miller, whose clients include patients referred by physicians, uses CBD in a variety of delivery modalities that she has found effective. “Patches can be worn for pain or anxiety management. Capsules or concentrated drops can be taken orally for pain, inflammation, sleep, and anxiety. Balms and creams can be used on the hands and feet to manage arthritic pain. Vaping is another delivery method,” she says.


And, if you do luck out and get a tincture truly containing CBD, you'll likely dish out $200 or so to take 10 to 40 milligrams daily. Since research participants take closer to 1,000 milligrams a day, it's hard to imagine a benefit without drinking the whole (expensive, calorie-dense) bottle, Tishler says. "Most people will adjust their doses based on what they're comfortable spending," Asquith says.


“Marijuana and industrial hemp are different varieties of the same plant species, Cannabis sativa L. Marijuana typically contains 3 to 15 percent THC on a dry-weight basis, while industrial hemp contains less than 1 percent (Blade, 1998; Vantreese, 1998). Most developed countries that permit hemp cultivation require use of varieties with less than 0.3 percent THC. However, the two varieties are indistinguishable by appearance. DeMeijer et al. (1992), in a study of 97 Cannabis strains, concluded that short of chemical analysis of the THC content, there was no way to distinguish between marijuana and hemp varieties.” http://www.ers.usda.gov/media/328202/ages001eb_1_.pdf
And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
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Quality is a particular concern, because cannabis plants easily soak up heavy metals from pesticides and other contaminants, Marcu says. If you are buying online, look for a company that documents how it tests its products. (If the website doesn’t indicate this, call and ask.) “Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.

Dr. Devinsky’s research, which was recently published in The New England Journal of Medicine, is beginning to provide that much-needed data in the field of epilepsy research. In a landmark multinational randomized double-blind study for a treatment-resistant form of the condition, subjects taking an oral solution of 20 mg CBD per kilogram of body weight for 14 weeks, along with standard treatment, experienced a 42 percent reduction in drop seizures (the muscles go limp). Those taking a 10 mg CBD per kilogram of body weight saw a 37 percent decrease; patients who got a placebo saw a 17.2 percent decrease. The mechanism hasn’t quite been worked out yet, Dr. Devinsky says, though there’s some evidence that a receptor known as GPR55 may be critical for the anti-seizure effect.
Full spectrum CBD also contains a variety of essential vitamins, minerals, fatty acids, protein, chlorophyll, terpenes, flavonoids, and fiber. When referring to CBD in the hemp plant, it’s important to understand that hemp contains a large number of cannabinoids (in trace amounts), but the main compound is cannabidiolic acid (CBDa). As CBDa is more abundant in the hemp plant, firms must decarboxylate the oil. This process heats the oil and changes CBDa into CBD.
CBD hemp oil has a huge range of potential health benefits and uses, including reducing pain, soothing anxiety, fighting chronic diseases, improving mood, eliminating depression, preventing inflammatory arthritis, protecting the immune system, balancing the metabolism, aiding sleep disorders, and healing the skin, among others. CBD oil can also be used in many different ways and has a variety of applications for natural health.
Many people are familiar with cannabidiol (CBD), which is found in highly concentrated amounts in our products, but there are actually dozens of cannabinoids found in hemp, which have shown many benefits in studies. We choose to make all our products with full-spectrum hemp oil, which includes all of the cannabinoids found in the plant, so you don’t miss out on any of the benefits.
Being a relatively inexpensive method it is preferred by small scale producers of CBD and THC oils. During extraction this method uses solvents like butane, ethanol and alcohol derived from grains. This method has several disadvantages the worst of which is potential of explosion while the second is leftover residue of these solvents. Scientists and doctors advice against the use of this method as it can make the end product unsafe for medical use and also can make existing medical condition much worse. When there are unsafe residues in CBD oil it reduces healing powers and can even compromise health of patients.
There's also the question of CBD's legality – something that's a lot grayer than the black-and-white picture most companies paint. The U.S. Drug Enforcement Administration considers CBD, like all cannabinoids, a schedule 1 drug. That means it's just as illegal as heroin and ecstasy. Meanwhile, hemp – a variety of the cannabis plant regulated by the U.S. Department of Agriculture – is legal , so long as its THC content is negligibly low. But because the agriculture department doesn't test for CBD – only THC – in hemp, more companies are getting away with selling products they say contain CBD, says Sara Jane Ward, an assistant professor of pharmacology at the Temple University Lewis Katz School of Medicine who's been studying CBD in rodent models for more than 10 years. Needless to say, the legality of CBD is "very confusing and very gray," she says.
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